Andrew Ellicott Douglass 1867-1962

Andrew Ellicott Douglass and the Giant Sequoias in the Founding of Dendrochronology

The Giant Sequoia played several crucial roles in the founding of the modern science of tree -ring dating. These included at least two central theoretical constructs and at least two minor ones; however, historical studies of dendrochronology are actively continuing and this list is expected to expand. Second only to the importance of the ponderosa pine (Pinus ponderosa) in the earliest days of...

Dmd052597 1867..1874

The primary objective of this study was to determine the in vivo absorption properties of valacyclovir, including the potential for saturable proton-coupled oligopeptide transporter 1 (PepT1)-mediated intestinal uptake, after escalating oral doses of prodrug within the clinical dose range. A secondary aim was to characterize the role of PepT1 on the tissue distribution of its active metabolite,...

The Complications of Coronary Arteriography By DOUGLASS

A nationwide survey was undertaken to determine the rate of complications due to coronary arteriography during 1970-71. The responses from 173 hospitals-including a total of 46,904 coronary arteriograms-were analyzed in relationship to the technique employed and to the number of examinations performed at each hospital during the two-year period. The overall mortality rate was 0.45% (brachial 0....

Dmd059089 1867..1872

Monoclonal antibodies (mAbs) represent an important class of therapeutic modalities. To optimize their pharmaceutical properties, studies have focused on improving mAb pharmacokinetic/ pharmacodynamic profiles by modulating their interactions with the neonatal Fc receptor (FcRn). The influence of both the chemical and physical properties of IgGs has been examined in the context of FcRn interact...

Modern Treatment Yearbook, 1962